By Altostrata, February 8, in Tapering. Olanzapine is an atypical antipsychotic with a number of serious drug interactions and side effects, weight gain, blood sugar elevation, and movement disorders among them. The amount of the decrease keeps getting smaller. Some people find they can go faster and some people find they have to go slower -- they can only tolerate decreases of a fraction of a milligram at a time.

Very careful tapering is necessary when you have had psychotic symptoms. Such symptoms can appear as withdrawal symptoms; that will cause you to become diagnosed as relapsed and re-medicated. Read Psychiatrist: Some patients are better off without antipsychotics Zyprexa - Tablets 2.

After oral administration, the mean terminal elimination half-life of olanzapine in healthy subjects varied on the basis of age and gender. In healthy elderly 65 and over versus non-elderly subjects, the mean elimination half-life was prolonged The pharmacokinetic variability observed in the elderly is within the range for the non-elderly. In female versus male subjects, the mean elimination half-life was somewhat prolonged Using tablets to taper Since olanzapine comes in many dosages, at least initially, tapering can take place using tablets and splitting them.

Plan your taper and, via prescription, convert any dosage to some number of lower-dosage tablets. This will enable tapering by a fraction of a milligram. It notes olanzapine is "practically insoluble in water.

You will need a prescription written for the custom-compounded liquid. The only drawback is this can be quite expensive. Using a liquid to taper: Make your own liquid However, like other drugs that are not particularly soluble, you can make a suspension, as our member Rhi explains. The preparation and stability of a liquid olanzapine preparation for oral administration in hospitals.

We have found that Zyprexa tablets 10mg, crushed and suspended in Guy's hospital "paediatric base", provides a more palatable liquid oral olanzapine preparation than crushed tablets suspended in water. Zyprexa tablets 3 x 10mg were halved and then crushed using a mortar and pestle and the powder suspended in 30ml Guy's hospital formula base for paediatric mixtures paediatric basea syrup-based mixture containing carboxymethylcellulose BP, methylhydroxybenzoate BP and propylhydroxybenzoate BP.

The suspension settled quickly and powdered tablet fragments formed a visible layer on the bottom of the glass bottle. Experience with the analogous clozapine suspension3 has shown that the need for vigorous shaking must be emphasised to nursing staff who may be asked to administer the suspension to patients. As with the clozapine suspension, informal assessment of the palatability of the olanzapine suspension has shown it to be well tolerated, some patients in fact preferring it to tablets.

No tests of microbiological stability have been performed although paediatric base is preserved. It therefore seems prudent to recommend a shelf-life of two weeks when the product is stored in a refrigerator. Such a shelf-life is adequate for hospital use. We have no information on the bioavailability of olanzapine from the suspension, although it seems unlikely that olanzapine bioavailabilty will prove to be less than that from Zyprexa tablets.

Guy's hospital "paediatric base" appears similar to Ora-Plus suspension base, which is commercially available:. Purified water, microcrystalline cellulose, carboxymethylcellulose sodium, xanthan gum, carrageenan, calcium sulfate, trisodium phosphate, citric acid and sodium phosphate as buffers, dimethicone antifoam emulsion.

Preserved with methylparaben and potassium sorbate Using orally disintegrating Zyprexa tablets or wafers to taper Orally disintegrating tablets ODT or wafers, which dissolve in the mouth, come in a range of dosages see above.

Conceivably, one might very carefully cut up the wafers to taper, but they may be difficult to cut accurately. I haven't done this and don't know of anyone who has, please let us know if you try this.

olanzapine how to safely stop

Making a liquid with water would seem to be a better way to taper utilizing these tablets or wafers. In fact, in Europe, patient instructions for the orally disintegrating tablets state.Medically reviewed by Drugs.

Olanzapine is an antipsychotic medication that is used to treat psychotic conditions such as schizophrenia and bipolar disorder manic depression in adults and children at least 13 years old. Olanzapine is also used together with fluoxetine Prozac to treat episodes of depression in adults and children at least 10 years old who have bipolar I disorder. Olanzapine is not approved for use in older adults with dementia -related psychosis.

olanzapine how to safely stop

Olanzapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Alzheimer's disease. Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.

If you get pregnant, tell your doctor right away. Do not stop taking olanzapine without your doctor's advice. Olanzapine can pass into breast milk. If you are breastfeeding, tell your doctor if you notice severe drowsiness, irritability, feeding problems, tremors, or unusual muscle movements in the nursing baby. The olanzapine orally disintegrating tablet Zyprexa Zydis may contain phenylalanine. Tell your doctor if you have phenylketonuria PKU.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Use the medicine exactly as directed. Remove an orally disintegrating tablet Zyprexa Zydis from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing.

Swallow several times as the tablet dissolves. Olanzapine can cause high blood sugar hyperglycemia. If you are diabetic, check your blood sugar levels on a regular basis. You may gain weight or have high cholesterol and triglycerides types of fat while taking olanzapine, especially if you are a teenager. You may need frequent blood tests.

Do not stop using olanzapine suddenly, even if you feel fine. Stopping suddenly may cause serious side effects. Olanzapine is sometimes used together with other antipsychotic medications or antidepressants. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

Why I Stopped Taking My Psych Medication

Medication may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor's instructions. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Overdose symptoms may include drowsiness, agitationaggression, slurred speech, confusion, increased heart rate, jerky or uncontrolled muscle movements, trouble breathing, or fainting.

Avoid driving or hazardous activity until you know how olanzapine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine.I was prescribd Zyprexa 2. It worked very well to begin with, but now I don't see the benefit. I started having a lot of bad side effects; weight gain, sweating, feet swelling, terrible hunger pains, restless leg syndrome is worse and shortness of breath.

I have high blood pressure, which is controlled. Now I feel as though I'm going through some type of withdrawal; cold sweats,weakness, stomach upset, and I have to keep going to lie down. Could this be withdrawal? Drezzy, No, you cannot stop taking Zyprexa cold turkey. It could throw your system into shock or cause you to experience manic or psychotic episodes.

You ask your doctor to help you taper off of the med. Hope this helps.

olanzapine how to safely stop

Zyprexa is a member of the same family of what we sometimes call " evil drugs" though the dosage was small it is enough to get your body "hooked" You must wean off if it the same as almost all anti depressants and depressants alike.

If you went cold turkey on your own you can and most likely are having some terrible side effects. If your doc did that, shame on him, but the drug comapnies themselves should put those warnings out there, and they don't so the doc is not all to blame.

Hope you feel better. I was on 5 mg of zyprexa for 6 months and I just stopped three days ago because I can't afford to go to the doctor until I get my work insurance in a few months. I feel amazing!!! I think I am having the best manic episode of my life. Still looking for answers? Try searching for what you seek or ask your own question. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.Posted 11 years ago83 users are following.

olanzapine how to safely stop

I have been on Olanzapine or over 6 years now from when I was diagnosed Borderline personality traits and all I can say is that I have endured 6 years of living hell. I have been taking 10mg every night for that time and piled on loads of weight, felt lethargic no confidence and started experiencing heart pains. I have had absolutely zero social life in that time and felt unable to think or communicate with other people.

I decided just over a month ago to stop the treatment and now am starting to feel much better. I have lost a stone in 2 weeks and look much better ,I am now able to think clearly and have much more energy and motivation to do things. To help me stop the Olanzapine I have avoided alcohol completely this always put me back to square one in the past.

I am finding it difficult to get off to sleep without the aid of the drug but more excercise through the day is helping with this. I will never return to taking this drug again as I feel it has robbed me of 6 years of my life. Posted 10 years ago. I'm trying to come off olanzapine but I get muddled thoughts till I have 2. Is there anything that can help with that while coming off olanzapine?

Posted 2 years ago. I am reducing from 7. Olanzapine is overused- prescribed for any number of mental conditions because it has a mind numbing effect. Be guided by your psych but remember; no one knows you better than yourself.

It is not a practice run. Posted 7 years ago. Posted 5 years ago. Posted 4 years ago. Emis Moderator comment: I have removed the email address as we do not publish these in the forums. If users wish to exchange contact details please use the Private Message service. Not after reading the horror stories from people on this med. Thanks for 'listening'.

Hi Christinejus been reading one of your posts on this forum. I do hope your improving trying to come down off sum of your medications.Olanzapine Tablets, USP oh lan' za peen Read the Medication Guide that comes with olanzapine tablets before you start taking them and each time you get a refill.

There may be new information. This Medication Guide does not take the place of talking to your doctor about your medical condition or treatment. Talk with your doctor or pharmacist if there is something you do not understand or you want to learn more about olanzapine tablets. What is the most important information I should know about olanzapine tablets? Olanzapine tablets may cause serious side effects, including:. Your doctor should do tests to check your blood sugar before you start taking olanzapine tablets and during treatment.

In people who do not have diabetes, sometimes high blood sugar goes away when olanzapine tablets are stopped. People with diabetes and some people who did not have diabetes before taking olanzapine tablets need to take medicine for high blood sugar even after they stop taking olanzapine tablets. Call your doctor if you have any of these symptoms of high blood sugar hyperglycemia while taking olanzapine tablets:.

High fat levels in your blood cholesterol and triglycerides. High fat levels may happen in people treated with olanzapine tablets, especially in teenagers 13 to 17 years oldor when used in combination with fluoxetine in children 10 to 17 years old.

You may not have any symptoms, so your doctor should do blood tests to check your cholesterol and triglyceride levels before you start taking olanzapine tablets and during treatment. Weight gain. Weight gain is very common in people who take olanzapine tablets. Teenagers 13 to 17 years old are more likely to gain weight and to gain more weight than adults. Children 10 to 17 years old are also more likely to gain weight and to gain more weight than adults when olanzapine tablets are used in combination with fluoxetine.

Some people may gain a lot of weight while taking olanzapine tablets, so you and your doctor should check your weight regularly.

Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising. What are olanzapine tablets?

Olanzapine tablets are a prescription medicine used to treat:. Olanzapine tablets have not been approved for use in children under 13 years of age.

Coming off Olanzapine

Olanzapine tablets in combination with fluoxetine has not been approved for use in children under 10 years of age. The symptoms of schizophrenia include hearing voices, seeing things that are not there, having beliefs that are not true, and being suspicious or withdrawn.

The symptoms of bipolar I disorder include alternating periods of depression and high or irritable mood, increased activity and restlessness, racing thoughts, talking fast, impulsive behavior, and a decreased need for sleep.

Some of your symptoms may improve with treatment. If you do not think you are getting better, call your doctor. What should I tell my doctor before taking olanzapine tablets? Olanzapine tablets may not be right for you. Before starting olanzapine tablets, tell your doctor if you have or had:.

Tell your doctor if you exercise a lot or are in hot places often. The symptoms of bipolar I disorder or schizophrenia may include thoughts of suicide or of hurting yourself or others. If you have these thoughts at any time, tell your doctor or go to an emergency room right away. Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Olanzapine tablets and some medicines may interact with each other and may not work as well, or cause possible serious side effects.

Your doctor can tell you if it is safe to take olanzapine tablets with your other medicines. Do not start or stop any medicine while taking olanzapine tablets without talking to your doctor first.Olanzapine "oh-LAN-za-peen" is an atypical antipsychotic medicine which can be used to treat mania, schizophrenia and bipolar disorder. This page will give you general information about olanzapine. Always talk to your doctor about your situation and whether this medication is for you.

Elizabeth tells her story of taking olanzapine and sertraline for anorexia. Medication type: atypical antipsychotic. What can it be used for? If you are 18 or over, the doctor can prescribe olanzapine for you as a licensed medicine for maniaschizophrenia and bipolar disorder. There is less research about its use and effectiveness in people under There are many companies making olanzapine tablets and the orodispersible ones.

The non-active ingredients are likely to vary so if you have intolerances to certain sugars e. If you need to avoid animal products such as gelatin, please note that this is often found in capsules but also in some tablet formulations. Ask your pharmacist if you have any questions about the ingredients.

There is a naturally-occurring chemical messenger 'neurotransmitter' in the brain called dopaminewhich is mainly involved in thinking, emotions, behaviour and perception.

With some illnesses, dopamine may be overactive, which upsets the normal balance of chemicals in the brain and can produce a variety of symptoms.

The main effect that olanzapine has is to block some dopamine receptors in the brain, correcting the overactivity of dopamine. Olanzapine also has effects on other neurotransmitters in the brain such as serotonin 5-HTwhich may also contribute to its beneficial effects. It can take four to six weeks for olanzapine to show its full effects, but s ome studies show a good effect for some people within the first week of taking it.

You should stay in touch with your doctor to see how it goes over the first few weeks. They might do some tests to check your symptoms. If you have had no good effects after two to three weeks, your doctor may increase the dose or change the medicine. Your doctor might start you on a low dose and then increase it slowly over two to four weeks to your full dose.

If you switch from olanzapine tablets to the injection, you may need to continue taking your tablets for the first few weeks after your first injection, as the injection takes a few weeks to kick in.

You and your doctor should talk about how long you need to take olanzapine before you start your treatment. If you stop the olanzapine, you will go back for checks to see that your old symptoms do not come back. For psychosis or schizophreniaif you have had one episode of illness, then it is best for you to keep taking olanzapine for at least two years to reduce the chances of becoming ill again.

If you have had more than one episode of illness, then a period of at least five years is recommended. If you are taking olanzapine to treat bipolar mania or bipolar depression, then you will need to discuss long-term medicines for your bipolar disorder with your doctor.Learn More.

Or in a crisistext "NAMI" to Donate Now. All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication. Olanzapine is a medication that works in the brain to treat schizophrenia.

Olanzapine discontinuation leads to higher relapse in depression with psychosis

It is also known as a second generation antipsychotic SGA or atypical antipsychotic. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. This medication sheet will focus primarily on schizophrenia. You can find more information about bipolar disorder and depression here. Olanzapine may also be helpful when prescribed "off-label" for prevention of chemotherapy-associated acute and delayed nausea or vomiting, chemotherapy-associated breakthrough nausea or vomiting, delirium, delusional parasitosis, post-traumatic stress disorder, Tourette syndrome, and other mental health conditions.

Your mental health provider should justify his or her thinking in recommending and "off-label" treatment. They should be clear about the limits of the research around that medication and if there are any other options. Schizophrenia requires long-term treatment. Do not stop taking olanzapine, even when you feel better.

With input from you, your health care provider will assess how long you will need to take the medicine. Do not stop taking olanzapine or change your dose without talking with your healthcare provider first.

For olanzapine to work properly, it should be taken every day as ordered by your healthcare provider. If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a complex decision since untreated schizophrenia has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Symptoms in the newborn may include agitation, feeding disorder, hypertonia, hypotonia, respiratory distress, somnolence, and tremor; these effects may be self-limiting or require hospitalization. Caution is advised with breastfeeding since olanzapine does pass into breast milk. It is recommended that women receiving olanzapine should not breast-feed.


Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks. The oral dose usually ranges from 5 mg to 20 mg.

The dose of the injection usually ranges from mg to mg. Only your healthcare provider can determine the correct dose for you. Olanzapine orally disintegrating tablets must remain in their original packaging.

Open the package with clean dry hands before each dose. Do not try to put tablets in a pillbox if you take the orally disintegrating tablets. Olanzapine orally disintegrating tablets will dissolve in your mouth within seconds and can be swallowed with or without liquid. Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication.

You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication. The long-acting injection form of olanzapine is administered every 2 to 4 weeks. It should be administered by your health care professional through an injection into your buttocks area.